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Question · Low mood

Does magnesium help with low mood?

Many say yes, going by Reddit owner reports: 21 of 32 rated comments from people who describe low mood or depression describe a good experience with Magnesium, and 10 describe a poor one. That is self-reported experience, not proof that it works, and results vary from person to person.

Magnesium, Low mood	Owner comments
Rated comments in this context	32
Positive	21 (66%)
Negative	10 (31%)
Describe an unwanted effect	6
Context rating (small samples pulled to the average)	3.3

Magnesium (form not stated) overall: 4.1 from 438 owner comments in Reddit anxiety, stress and supplement communities, May 2026 to October 2026.

What the research says

Magnesium is a mineral the body uses in hundreds of enzyme reactions. Supplements come in many forms (oxide, citrate, glycinate and others) that differ in how much magnesium they contain and how well it is absorbed.^{[NIH Office of Dietary Supplements]}
A 2017 systematic review found the evidence on magnesium and subjective anxiety suggestive but of poor quality.^[PubMed]

Safety

The NIH upper limit for magnesium from supplements is 350 mg a day for adults; higher doses commonly cause diarrhea, nausea and abdominal cramping.^{[NIH Office of Dietary Supplements]}
Magnesium can reduce the absorption of some antibiotics (tetracyclines, quinolones) and bisphosphonates, so the NIH advises spacing the doses apart.^{[NIH Office of Dietary Supplements]}

Good experiences

4/5 Mood
“I soo agree I take vit d3 with k2 and magnesium glycerine at night it has really helped me with mood and just the way my body feels”

owner comment via r/Supplements · 2026-08-06 · 3 upvotes

4/5 Mood
“magnesium helps a lot for sleeping too but makes me have a more flat mood.”

owner comment via r/Anxiety · 2026-10-21 · 2 upvotes

4/5 Mood
“I have been using saffron alongside l-theanine and magnesium in a product called mood mod and it's been great for me.”

owner comment via r/Supplements · 2026-09-03 · 2 upvotes

Poor experiences

2/5 Feeling flat or numbMood
“I get anhedonia when I'm taking too much magnesium.”

owner comment via r/Nootropics · 2026-09-13 · 7 upvotes

2/5 Feeling flat or numbMood
“For me it's the magnesium, because I tried all the different types, magnesium gives me insane anhedonia and depression.”

owner comment via r/Supplements · 2026-10-12 · 2 upvotes

How reports compare in other contexts

Context	Rated comments	Positive	Negative
Anxiety & worry	67	43	19
Everyday stress	50	41	4
Panic attacks	15	6	8
Physical tension	11	6	4

More on Magnesium

Talk to a doctor about new, severe or lasting symptoms, and to a pharmacist before combining supplements with medicines.