Medical disclaimer: CalmVerdict summarizes what people say about supplements on Reddit. It is not medical advice, and nothing here is meant to diagnose, treat, cure, or prevent any disease. These statements have not been evaluated by the Food and Drug Administration. Talk to your doctor or pharmacist before starting a supplement, especially if you take an antidepressant or other medicine, are pregnant, or have a medical condition. Do not stop or change prescribed medicine on your own. If you are in crisis or thinking about suicide, call or text 988 (US) or your local emergency number. Full disclaimer.

Glycine vs Magnesium glycinate

On Reddit, owners rate Magnesium glycinate higher overall (4.0 vs 3.0). Scores summarize self-reported experiences and are not evidence that either will work for you.

GlycineMagnesium glycinate
Typepowder or capsulescapsules or powder
CalmVerdict score3.04.0
Owner sentiment3.23.5
Recommendations1.04.8
Tolerability4.04.4
Owner comments77370
Rated comments42228
Unwanted effects reported19%14%
Top praiseCalming effect, Dose & timingCalming effect, Dose & timing
Top complaintsSide effects, Calming effectSide effects, Dose & timing

By concern

ContextGlycineMagnesium glycinate
Anxiety & worry5 of 19 positive43 of 114 positive
Low mood3 of 16 positive13 of 41 positive
Everyday stress4 of 11 positive33 of 56 positive
Panic attacks0 of 3 positive8 of 20 positive
Rumination & intrusive thoughts1 of 7 positive2 of 6 positive
Physical tensionToo few comments6 of 14 positive
PMS & PMDD moodToo few comments2 of 3 positive

What owners say about Glycine

5/5 Taste & form

“Glycine is what I swear by. One teaspoon with green tea in the morning and one before sleep. I took it primarily for collagen but with time noticed the effect of calmness, it is now harder for me to become agitated and stressed.”

owner comment via r/Supplements · 2026-06-04 · 18 upvotes
2/5 Side effects

“i experience a paradoxical effect to glycine, it gives me extreme anxiety & insomnia.”

owner comment via r/Supplements · 2026-09-08 · 17 upvotes
3/5 MoodSide effects

“I've also had some very weird reactions to iron bisglycinate that are pretty confounding considering the amount of glycine in that is \*extremely\* low compared to the amounts we get in food.”

owner comment via r/Nootropics · 2026-10-23 · 2 upvotes

Full Glycine page →

What owners say about Magnesium glycinate

2/5 Falling asleepTakes time

“Started magnesium glycinate for sleep, didn't really knock me out but after two weeks I noticed my jaw wasn't clenched into a fist all day.”

owner comment via r/Supplements · 2026-08-13 · 35 upvotes
4/5

“Magnesium glycinate, improved my sleep, fewer muscle twitches, and helped me feel less tension etc.”

owner comment via r/Supplements · 2026-05-11 · 28 upvotes
4/5 Calming effect

“Magnesium glycinate also helps me chill out when my brain won't stop racing but takes maybe an hour to kick in”

owner comment via r/Supplements · 2026-05-05 · 24 upvotes

Full Magnesium glycinate page →

More detail: Magnesium glycinate side effects · Magnesium glycinate dosage and timing

Talk to a doctor or pharmacist before switching or combining supplements, particularly if you take other medicines.